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Lyophilization of liposomal drug forms (Review)

  • DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY
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Pharmaceutical Chemistry Journal Aims and scope

Lyophilization is a promising approach to ensuring the long-term stability of liposomes. Decades of studies in this field have revealed various cryoprotective mechanisms such as water replacement and formation of a cryoprotector matrix. Much progress has been made in obtaining highly stable liposomes after lyophilization based on optimization of the formulation and process parameters. This paper reviews cryoprotective mechanisms, their parameters affecting the cryoprotective effect, and techniques used most often in the studies. The parameters are discussed with respect to two aspects, namely, formulation factors (choice of the lipid bilayer composition, vesicle size, selection of cryoprotectors, dry mass ratio of cryoprotector to lipid, distribution of cryoprotector on both sides of the lipid bilayer) and processing factors (freezing protocols, drying protocols, etc.).

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Authors and Affiliations

  1. Blokhin Russian Oncological Research Center, Russian Academy of Medical Sciences, Moscow, 115478, Russia

    O. Yu. Arshinova, E. V. Sanarova, A. V. Lantsova & N. A. Oborotova

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  1. O. Yu. Arshinova
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  2. E. V. Sanarova
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  3. A. V. Lantsova
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  4. N. A. Oborotova
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 46, No. 4, pp. 29 – 34, April, 2012.

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Arshinova, O.Y., Sanarova, E.V., Lantsova, A.V. et al. Lyophilization of liposomal drug forms (Review). Pharm Chem J 46, 228–233 (2012). https://doi.org/10.1007/s11094-012-0768-2

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  • DOI: https://doi.org/10.1007/s11094-012-0768-2

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