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Antiproliferative Evaluation of (E)-3-(3-(Allyloxy)-2-Methoxyphenyl)-1-(2,4,6-Trimethoxyphenyl)Prop-2-En-1-One as a Novel Apoptosis Inducer Against Prostate Cancer PC-3 Cells

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(E)-3-(3-(Allyloxy)-2-methoxyphenyl)-1-(2,4,6-trimethoxyphenyl)prop-2-en-1-one displayed potent antiproliferative activity against the PC-3 cell line. For colony assay, it can inhibit the colony formation at a concentration of 10 μM. Morphological changes of PC-3 cells were determined using DAPI (4′,6-diamidino-2-phenylindole) staining and chromatin condensation. Treatment with this compound at 10 μM induced apoptosis from 2.0% to 30.4% compared with control according to flow cytometry analysis. It also induced the downregulation of apoptosis-related markers Bcl-2 and XIAP (X-linked inhibitor of apoptosis protein). However, treatment with NAC (N-acetyl-L-cysteine) almost completely attenuated chalcone-induced cell inhibition and cell apoptosis in PC-3 cells.

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Acknowledgments

This work was supported by the National Natural Sciences Foundations of China (Project Nos. 81703541 and 81673322) and project funded by the China Postdoctoral Science Foundation. This work was also supported by MEDCHEMEXPRESS. Thanks to MCE Award for Scientists Promoting Biology and Medicine Research.

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  1. Dong-Jun Fu contributed equally to this work.

Authors and Affiliations

  1. School of Pharmaceutical Sciences and Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou University, Zhengzhou, 450001, China

    Dong-Jun Fu & Ming-Chao Zhu

  2. School of Basic Medicine, Zhengzhou University, Zhengzhou, 450001, China

    Ping Li, Si-Chen Li, Guo Zheng, Rui Zhang, Sai-Yang Zhang & Jiang-Feng Li

  3. The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, 450014, China

    Yi-Rui Kuang & Li-Le Jiang

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  1. Dong-Jun Fu
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Correspondence to Sai-Yang Zhang or Jiang-Feng Li.

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Fu, DJ., Li, P., Kuang, YR. et al. Antiproliferative Evaluation of (E)-3-(3-(Allyloxy)-2-Methoxyphenyl)-1-(2,4,6-Trimethoxyphenyl)Prop-2-En-1-One as a Novel Apoptosis Inducer Against Prostate Cancer PC-3 Cells. Pharm Chem J 52, 917–922 (2019). https://doi.org/10.1007/s11094-019-01926-z

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  • DOI: https://doi.org/10.1007/s11094-019-01926-z

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