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Determination of Bacterial Endotoxins in Drugs: False-Negative Results

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Pharmaceutical Chemistry Journal Aims and scope

One of the possible causes of false-negatives in bacterial endotoxin determinations, endotoxin aggregation and adsorption, was examined in a model experiment (positive control). A solution for eliminating the interfering actor using kinetic methods and a dispersing solvent was proposed based with the drug caspofungin as an example.

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Authors and Affiliations

  1. Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation, 8/2 Petrovskii Blvd., Moscow, 127051, Russia

    O. V. Shapovalova, N. P. Neugodova, G. A. Sapozhnikova, L. V. Simutenko & A. A. Agashirinova

Authors
  1. O. V. Shapovalova
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  2. N. P. Neugodova
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  3. G. A. Sapozhnikova
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  4. L. V. Simutenko
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  5. A. A. Agashirinova
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 51, No. 12, pp. 47 – 50, December, 2017.

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Shapovalova, O.V., Neugodova, N.P., Sapozhnikova, G.A. et al. Determination of Bacterial Endotoxins in Drugs: False-Negative Results. Pharm Chem J 51, 1119–1122 (2018). https://doi.org/10.1007/s11094-018-1751-3

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  • DOI: https://doi.org/10.1007/s11094-018-1751-3

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