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Development of a Procedure for Identification of Biperiden Hydrochloride with Specificity for Triperiden Hydrochloride

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Pharmaceutical Chemistry Journal Aims and scope

Biperiden hydrochloride, (1RS)-1-[(1RS, 2SR, 4RS)-bicyclo[2.2.1]hept-5-en-2-yl]-1-phenyl-3-(piperidin-1-yl)prop an-1-ol hydrochloride, is one of the most efficacious cholinolytics. It is used to treat Parkinson’s disease and various types of muscular spasms and to ameliorate uncoordinated muscular movements that can accompany the use of several tranquilizers [1, 2]. Biperiden appears in the vital and essential drug list that was approved by an order of the RF Government [3].

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References

  1. E. Wezenberg, R. J. Werkes, B. G. C. Sabbe, et al., Psychopharmacology, 181, 582 – 594 (2005).

    Article  CAS  PubMed  Google Scholar 

  2. O. S. Levin, N. N. Shindryaeva, and M. A. Anikina, Zh. Nevrol. Psikhiatr., 8, 69 – 74 (2012).

    Google Scholar 

  3. Order of the RF Government No. 2323-p dated Oct. 23, 2017; http://www.garant.ru

  4. N. V. Yurgel’ (ed.), Handbook for Drug Analytical Method Validation [in Russian], Sport i Kul’tura-2000, Moscow (2007), p. 18.

  5. Monograph 01 / 2017:1074, Biperiden hydrochloride, in: European Pharmacopoeia, 9th Ed., Vol. 1, European Department for the Quality of Medicines & Health Care, Strasbourg (2016), pp. 1848 – 1850.

  6. M. G. Kadieva, E. T. Oganesyan, and S. Kh. Mutsueva, Khim.-farm. Zh., 39(11), 3 – 11 (2005); Pharm. Chem. J., 39(11), 565 – 573 (2005).

  7. H. E. Gottlieb, V. Kotlyar, and A. Nudelman, J. Org. Chem., 62(21), 7512 – 7515 (1997).

    Article  CAS  PubMed  Google Scholar 

  8. W. Klavehn, US Pat. No. 2,789,110, Apr. 16, 1957; https://www.google.com/patents/US2789110

  9. D. O. Cowan, N. G. Kireghoff, J. E. Norlander, et al., J. Org. Chem., 32, 2639 – 2640 (1967).

    Article  CAS  Google Scholar 

  10. A. J. Gordon and R. A. Ford, The Chemist’s Companion, Wiley-Interscience, New York (1972).

    Google Scholar 

  11. M. Grosse, Doctoral Dissertation, Kaiserlauten (2001).

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Authors and Affiliations

  1. Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation, Moscow, 127051, Russia

    N. E. Kuz’mina, S. V. Moiseev, V. I. Krylov, A. A. Kutin, V. A. Yashkir & V. A. Merkulov

Authors
  1. N. E. Kuz’mina
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  2. S. V. Moiseev
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  3. V. I. Krylov
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  4. A. A. Kutin
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  5. V. A. Yashkir
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  6. V. A. Merkulov
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Corresponding author

Correspondence to S. V. Moiseev.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 51, No. 12, pp. 34 – 38, December, 2017.

A. A. Kutin is deceased.

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Kuz’mina, N.E., Moiseev, S.V., Krylov, V.I. et al. Development of a Procedure for Identification of Biperiden Hydrochloride with Specificity for Triperiden Hydrochloride. Pharm Chem J 51, 1106–1110 (2018). https://doi.org/10.1007/s11094-018-1749-x

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  • DOI: https://doi.org/10.1007/s11094-018-1749-x

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