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Synthesis, Characterization and Antimicrobial Activity of Two Novel Sulfonamide Schiff Base Compounds

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Pharmaceutical Chemistry Journal Aims and scope

Reactions of 2-hydroxy-3-methoxybenzaldehyde with p-toluenesulfonyl hydrazide and 4-nitrosulfonyl hydrazide under classical heating led to the corresponding sulfonamide Schiff bases 1 and 2. Both synthesized compounds were characterized by their spectroscopic data and elemental analysis. The antimicrobial activity of 1 and 2 against Gram-positive bacteria Staphylococcus epidermidis and Staphylococcus saprophyticus and Gram-negative bacteria Proteus mirabilis has been investigated by disc diffusion and minimum inhibitory concentration (MIC) methods. The disc diffusion method was also used to study antifungal activity of compounds against Aspergillus fumigates, Aspergillus clavatus, and Aspergillus flavus. Vancomycin and sulfamethoxazole/trimethoprim were used as standard drugs for bacteria and miconazole was used as antifungal standard.

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Authors and Affiliations

  1. Department of Chemistry Science and Research Branch, Islamic Azad University, Tehran, Iran

    Mozhgan Tahriri, Mohammad Yousefi & Kheirollah Mehrani

  2. Department of Chemistry, Yazd Branch, Islamic Azad University, Yazd, Iran

    Masoumeh Tabatabaee

  3. Department of Biology, Ashkezar Branch, Islamic Azad University, Yazd, Iran

    Mahmood Dehghani Ashkezari

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  1. Mozhgan Tahriri
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  2. Mohammad Yousefi
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  3. Kheirollah Mehrani
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  4. Masoumeh Tabatabaee
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  5. Mahmood Dehghani Ashkezari
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Correspondence to Masoumeh Tabatabaee.

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Tahriri, M., Yousefi, M., Mehrani, K. et al. Synthesis, Characterization and Antimicrobial Activity of Two Novel Sulfonamide Schiff Base Compounds. Pharm Chem J 51, 425–428 (2017). https://doi.org/10.1007/s11094-017-1626-z

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  • DOI: https://doi.org/10.1007/s11094-017-1626-z

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