Aminomethylation of 1-(4-ethoxyphenyl)-2-phenylethanone yielded 3-(4-benzylpiperazin-1-yl)-1-(4-ethoxyphenyl)-2-phenylpropan-1-one. Reduction of this compound with lithium aluminum hydride produced 3-(4-benzylpiperazin-1-yl)-1-(4-ethoxyphenyl)-2-phenylpropan-1-one, and interaction of this with Grignard reagents produced 3-(4-benzylpiperazinyl)-1-(4-ethoxyphenyl)-1-alkyl(aryl)-2-phenylpropan-1-ones. Some of the dihydrochlorides of the resulting compounds were found to have anti-inflammatory, analgesic, and peripheral n-cholinolytic activity.
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G. A. Gevorgyan, A. P. Avakyan, N. K. Gasparyan, and G. A. Panosyan, Zh. Organ. Khimii, 45(12), 1854 – 1856 (2009).
L. I. Kas’yan and V. A. Pal’chikov, Zh. Organ. Khimii, 46(1), 1 – 18 (2010).
N. K. Gasparyan, G. A. Gevorgyan, R. G. Paronikyan,, et al., Khim-Farm. Zh., 39(7), 23 – 25 (2005); Pharm. Chem. J., 39(7), 361 – 363 (2005).
N. K. Gasparyan, A. E. Tumadzhyan, G. A. Panosyan, and G. A. Gevorgyan, Khim-Farm. Zh., 43(7), 16 – 18 (2009); Pharm. Chem. J., 43(7), Article 389 (2009).
Guidelines for Preclinical Studies of Medicines [in Russian], A. N. Mironov, N. D. Bunyatyan, et al. (eds.), Ministry of Health and Social Development of the Russian Federation, Scientific Center for Assessment of Medicines, Moscow (2012), Part 1.
L. Randall and J. Selitto, Arch. Int. Pharmacodyn, 111, 209 (1957).
N. A. Apoyan, Biol. Zh. Armenii, 34(6), 516 – 518 (1983).
D. A. Xarkevich, Guidelines for Practical Training in Pharmacology [in Russian], Meditsina, Moscow (1981)
M. L. Belen’kii, Elements of the Quantitative Assessment of Pharmacological Effects [in Russian], Medgiz, Leningrad (1963).
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 51, No. 1, pp. 31 – 34, January, 2017.
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Gevorgyan, G.A., Gasparyan, N.K., Papoyan, O.A. et al. Synthesis and Various Biological Properties of 3-(4-Benzylpiperizino)-1-(4-Ethoxyphenyl)-1-Alkyl(Aryl)-2-Phenylpropan-1-OL Dihydrochlorides. Pharm Chem J 51, 30–34 (2017). https://doi.org/10.1007/s11094-017-1552-0
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DOI: https://doi.org/10.1007/s11094-017-1552-0