Three-component condensation of thiourea, ethyl acetoacetic ester, and anisaldehyde was performed to synthesize ethyl-4-(4-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate. This compound interacted with aromatic aldehydes to yield the corresponding styryl derivatives. The hypotensive activity of the compounds synthesized here was assessed.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 50, No. 7, pp. 18 – 20, July, 2016.
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Fazylov, S.D., Nurkenov, O.A., Zhivotova, T.S. et al. Synthesis and Hypotensive Activity of Novel Styryl Derivatives Based on Ethyl-4-(4-Methoxyphenyl)-2-Thioxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate. Pharm Chem J 50, 440–442 (2016). https://doi.org/10.1007/s11094-016-1466-2
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DOI: https://doi.org/10.1007/s11094-016-1466-2