Amethod for determining molar substitution of hydroxyethylstarches by 1H NMR spectroscopy was validated in terms of specificity, linearity, correctness, precision, and range of application. The method can be used to evaluate the parameter “molar substitution” in the framework of pharmacological expert assessment of hydroxyethylstarches as components of medicines.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 50, No. 4, pp. 47 – 51, April, 2016.
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Kuz’mina, N.E., Moiseev, S.V., Krylov, V.I. et al. Validation of a Method for Measuring the Molar Substitution of Hydroxyethylstarches by 1H NMR Spectroscopy. Pharm Chem J 50, 265–269 (2016). https://doi.org/10.1007/s11094-016-1435-9
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DOI: https://doi.org/10.1007/s11094-016-1435-9