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Physicochemical Properties and Methods for the Determination of Metformin Hydrochloride (A Review)

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Pharmaceutical Chemistry Journal Aims and scope

Metformin hydrochloride is widely used to treat diabetes mellitus. This review presents its physical and chemical properties and discusses methods of analysis that allow a quality assessment of metformin hydrochloride both as an individual drug and in combination with other antidiabetic medicines. The most widely used method is HPLC combined with spectrophotometry and other methods of analysis. The review is based on data from foreign and domestic articles and on our research results.

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Authors and Affiliations

  1. Parma Clinical LLC, 16 Prichal’naya St, Perm, 614113, Russia

    E. B. Polyakova, D. R. Sabirzyanov, N. A. Prozorova & A. B. Foteeva

  2. Perm State Pharmaceutical Academy, 2 Polevaya St, Perm, Perm Krai, 614990, Russia

    D. R. Sabirzyanov

Authors
  1. E. B. Polyakova
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  2. D. R. Sabirzyanov
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  3. N. A. Prozorova
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  4. A. B. Foteeva
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Correspondence to D. R. Sabirzyanov.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 55, No. 10, pp. 59 – 64, October, 2021.

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Polyakova, E.B., Sabirzyanov, D.R., Prozorova, N.A. et al. Physicochemical Properties and Methods for the Determination of Metformin Hydrochloride (A Review). Pharm Chem J 55, 1119–1125 (2022). https://doi.org/10.1007/s11094-021-02546-2

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  • DOI: https://doi.org/10.1007/s11094-021-02546-2

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