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Preparation of Biologically Active Film-Forming Materials Based on Polyphosphate-Modified Chitosan

  • DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY
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Pharmaceutical Chemistry Journal Aims and scope

The processes of preparing film-forming materials based on chitosan with surface modification and ionic cross-linking using sodium tripolyphosphate and potassium pyrophosphate respectively were studied. Optimum cross-linking conditions were identified by studying the interactions of chitosan with different levels of amino group protonation with polyphosphates with different numbers of ionized groups. These studies showed that changes in the duration of treatment of films allowed the level of swelling to be varied over the range 165% to 148% for potassium pyrophosphate and from 196% to 80% for sodium tripolyphosphate. Studies of the kinetics of study drug release showed that changes in the conditions used for modification with polyphosphates could increase the duration of release of the biologically active components to 8 h.

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Authors and Affiliations

  1. Moscow State Design and Technology University, Building 1, 33 Sadovincheskaya Street, 117997, Moscow, Russia

    M. A. Kasatkina & N. R. Kil’deeva

  2. N. A. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, 40 Obruchev Street, 117342, Moscow, Russia

    N. A. Budantseva

Authors
  1. M. A. Kasatkina
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  2. N. A. Budantseva
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  3. N. R. Kil’deeva
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 50, No. 4, pp. 32 – 39, April, 2016.

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Kasatkina, M.A., Budantseva, N.A. & Kil’deeva, N.R. Preparation of Biologically Active Film-Forming Materials Based on Polyphosphate-Modified Chitosan. Pharm Chem J 50, 250–257 (2016). https://doi.org/10.1007/s11094-016-1432-z

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  • DOI: https://doi.org/10.1007/s11094-016-1432-z

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