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Synthesis, Antimicrobial and Anticancer Evaluation of 2-Azetidinones Clubbed with Quinazolinone

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Pharmaceutical Chemistry Journal Aims and scope

A novel series of 2-azetidinones clubbed with quinazolinone was synthesized using anthranilic acid. All the synthesized compounds were evaluated for their antimicrobial activity against two Gram positive bacterial strains (Bacillus subtilis and Staphylococcus aureus), one Gram negative bacterial strain (Escherichia coli) and two fungal strains (Candida albicans and Aspergillus niger). All the synthesized compounds were also screened for their anticancer activity against human breast cancer cell line, MCF-7. Results of antimicrobial and anticancer study indicate that compounds 12 and 5 (IC50 = 49.52 μM) are the most potent antimicrobial and anticancer agents, respectively.

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Authors and Affiliations

  1. Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001, India

    Aakash Deep, Pradeep Kumar & Balasubrmanian Narasimhan

  2. Collaborative Drug Discovery Research Group, Faculty of Pharmacy, Campus Puncak Alam, Universiti Teknologi MARA (UiTM), 42300, Bandar Puncak Alam, Selangor, Malaysia

    Lim Siong Meng & Kalavathy Ramasamy

  3. Brain Research Laboratory, Faculty of Pharmacy, Campus Puncak Alam, Universiti Teknologi MARA (UiTM), 42300, Bandar Puncak Alam, Selangor, Malaysia

    Rakesh Kumar Mishra & Vasudevan Mani

Authors
  1. Aakash Deep
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  2. Pradeep Kumar
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  3. Balasubrmanian Narasimhan
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  4. Lim Siong Meng
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  5. Kalavathy Ramasamy
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  6. Rakesh Kumar Mishra
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  7. Vasudevan Mani
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Correspondence to Balasubrmanian Narasimhan.

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Deep, A., Kumar, P., Narasimhan, B. et al. Synthesis, Antimicrobial and Anticancer Evaluation of 2-Azetidinones Clubbed with Quinazolinone. Pharm Chem J 50, 24–28 (2016). https://doi.org/10.1007/s11094-016-1392-3

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  • DOI: https://doi.org/10.1007/s11094-016-1392-3

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