2-Sulfanyl-substituted 3-ethyl-3H-spiro[benzo[h]quinazolin-5,1′-cyclohexane]-4(6H)-ones were synthesized by reacting 3-ethyl-2-thioxo-2,3-dihydro-1H-spiro[benzo[h]quinazolin-5,1′-cyclohexane]-4(6H)-one with halides. 2-Hydrazino-3-ethyl-3H-spiro[benzo[h]quinazolin-5,1′-cyclohexane]-4(6H)-one was prepared from 3-ethyl-2-methylthio-3H-spiro[benzo[h]quinazolin-5,1′-cyclohexane]-4(6H)-one and transformed into 1-sulfanyl-substituted triazolobenzoquinazolines. Several of the synthesized compounds exhibited high anti-monoamine oxidase and antitumor activity.
Similar content being viewed by others
References
A. I. Markosyan and Kh. S. Hakopyan, Electronic J. Nat. Sci., Natl. Acad. Sci., Rep. Arm., 1, 5 – 9 (2005).
A. I. Markosyan, Kh. S. Akopyan, F. G. Arsenyan, et al., Khim.-farm. Zh., 40(9), 18 – 22 (2006); Pharm. Chem. J., 40(9), 480 – 484 (2006).
A. I. Markosyan, S. V. Dilanyan, R. A. Kuroyan, et al., Khim.-farm. Zh., 29(4), 32 – 34 (1995); Pharm. Chem. J., 29(4), 259 – 261 (1995).
I. Sovadinova, L. Blaha, J. Janosek, et al., Environ. Toxicol. Chem., 25(5), 1291 – 1297 (2008).
B. Van Treist and G. J. Peters, Oncology, 57(3), 179 – 194 (1999).
M. Hanlon and R. Ferone, Cancer Res., 56(14), 3301 – 3306 (1996).
A. I. Markosyan, S. A. Pogosyan, M. S. Safaryan, et al., Khim.-farm. Zh., 41(4), 16 – 18 (2006); Pharm. Chem. J., 41(4), 193 – 196 (2006).
A. I. Markosyan, S. A. Gabrielyan, G. A. Panosyan, et al., Khim.-farm. Zh., 42(2), 6 – 9 (2008); Pharm. Chem. J., 42(2), 56 – 59 (2008).
A. I. Markosyan, Kh. S. Akopyan, F. G. Arsenyan, et al., Khim.-farm. Zh., 42(6), 7 – 11 (2008); Pharm. Chem. J., 42(6), 313 – 318 (2008).
A. I. Markosyan, Khim. Zh. Arm., 63(1), 107 – 114 (2010).
R. R. Safrazbekyan and R. S. Sukasyan, Vopr. Med. Khim., 16, 623 – 628 (1970).
Z. P. Sof’ina, A. B. Syrkin, A. Goldin, et al., Experimental Assessment of Antitumor Compounds in the USSR and USA [in Russian], Meditsina, Moscow (1980).
G. N. Pershin, Methods of Experimental Chemotherapy [in Russian], Medgiz, Moscow (1971).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 48, No. 12, pp. 15 – 18, December, 2014.
Rights and permissions
About this article
Cite this article
Markosyan, A.I., Gabrielyan, S.A., Arsenyan, F.G. et al. Synthesis and Biological Activity of New 3-Ethyl-2-Thioxo-2,3-Dihydro-1H-Spiro[Benzo[h]-Quinazolin-5,1′-Cyclohexane]-4(6H)-One Derivatives. Pharm Chem J 48, 783–786 (2015). https://doi.org/10.1007/s11094-015-1195-y
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11094-015-1195-y