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Estimation of the Linearity of Ubidecarenone Pharmacokinetics After Intravenous Administration

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The dynamics of ubidecarenone (coenzyme Q10) levels in rat blood plasma and liver were monitored for two days after i.v. injection of solubilized ubidecarenone at doses of 10 and 30 mg/kg. The kinetic curves of the drug in plasma were exponential for both doses. The areas under the concentration—time curves differed by 8.6 times for the 10 and 30 mg/kg doses. Normalization to the dose did not superimpose them. The drug accumulated gradually in liver with the areas under the concentration—time curves differing by a factor of 4.4. These data indicated that ubidecarenone pharmacokinetics in plasma and liver were nonlinear after intravascular injection.

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Acknowledgments

The studies were performed under the auspices of a grant from the Russian Scientific Foundation (Project No. 14-15-00126).

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Authors and Affiliations

  1. Department of Fundamental Medicine, M. V. Lomonosov Moscow State University, 31 Lomonosovskii Pr., Bldg. 5, Moscow, 119192, Russia

    E. I. Kalenikova, E. A. Gorodetskaya, M. A. Belousova, E. V. Kharitonova, O. G. Tokareva, O. Yu. Kulyak & O. S. Medvedev

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  1. E. I. Kalenikova
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  2. E. A. Gorodetskaya
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  3. M. A. Belousova
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  4. E. V. Kharitonova
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  5. O. G. Tokareva
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  6. O. Yu. Kulyak
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  7. O. S. Medvedev
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Corresponding author

Correspondence to E. I. Kalenikova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 48, No. 12, pp. 7 – 8, December, 2014.

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Kalenikova, E.I., Gorodetskaya, E.A., Belousova, M.A. et al. Estimation of the Linearity of Ubidecarenone Pharmacokinetics After Intravenous Administration. Pharm Chem J 48, 775–776 (2015). https://doi.org/10.1007/s11094-015-1193-0

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  • DOI: https://doi.org/10.1007/s11094-015-1193-0

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