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The Role of Humous Acids in Acqua di Fiuggi Mineral Water in Degrading Stones Formed in the Urinary Tract (Review)

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Pharmaceutical Chemistry Journal Aims and scope

This review presents data on the high efficacy of acqua di Fiuggi water in the treatment and prophylaxis of urinary stone disease. Acqua di Fiuggi is a natural oligomineral water with a strong diuretic effect. Its contents include the humic substances with which the soil of the Anticolana valley is enriched. Humous substances, which are natural macromolecules with complex, disordered moleculare structures, include humic acids and fulvic acids, which are key components of acqua di Fiuggi. These acids can disorder the crystal lattices of calcium salts (oxalates, phosphates, etc.) in kidney stones, forming soluble calcium complexes. The result is that stones dissolve and are eliminated from the human body via the natural pathway.

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References

  1. A. P. Evan, E. M. Worcester, F. L. Coe, et al., Urolithiasis, DOI 10.1007/s00240-014-0701-0 (2014).

  2. N. A. Lisovaya, Terra Medika, 1(9), (2006); http://terra-medica.spb.ru/ld12006/lisovaja.htm.

  3. S. A. Golovanov and V. V. Drozhzheva, Éksperim. Klin. Urol., No. 2, (2010); http://ecuro.ru/article/kristalloobrazuyushchaya-aktivnosti-mochi-pri-oksalatnom-urolitiaze.

  4. Yu. G. Alyaev, M. O. Antonova, G. M. Kuz’micheva, et al., Fundam. Issled., 99(1), 186 – 192 (2012).

    Google Scholar 

  5. Yu. G. Alyaev, A. V. Amosov, V. S. Saenko, et al., http://www.spafiuggi.it/spafiuggi/index.jsp?idz=29

  6. A. V. Kudinov. Author’s Abstract of Master’s thesis in Biological Sciences [in Russian], Tomsk (2012).

  7. A. Fraioli, S. De Angelis Curtis, G. Ricciuti, et al., Clin. Ter., 152(6), 347 – 351 (2001).

    CAS  PubMed  Google Scholar 

  8. N. Calace, G. D’Ascenzo, S. De Angelis Curtis, et al., Nephron, 81, Supplement 1, 93 – 97 (1999).

    Article  CAS  PubMed  Google Scholar 

  9. D. S. Orlov, Khimiya Pochv, Moscow State University Press, Moscow (1992).

    Google Scholar 

  10. D. Kleinhempel, Albrecht-Thaer-Archiv, 14(1), 3 – 14 (1970).

    CAS  Google Scholar 

  11. D. S. Orlov, Sorosovskii Obrazov Zh., No. 2, 56 – 63 (1997).

  12. M. V. Zykova, M. V. Belousov, A. M. Gur’ev, et al., Khim.-Farm. Zh., 47(12), 53 – 56 (2013); Pharm. Chem. J., 47(12), 675 – 678 (2014).

  13. I. V. Perminova, Author’s Abstract of Doctoral Thesis in Chemical Sciences, M. V. Lomonosov Moscow State University, Moscow (2000).

  14. I. V. Perminova, F. Frimmel, A. Kudryavtsev, et al., Environ. Sci. Technol., 37, 2477 – 2485 (2003).

    Article  CAS  PubMed  Google Scholar 

  15. A. Piccolo, S. Nardi, and G. Concheri, Chemosphere, 33(4), 595 – 602 (1996).

    Article  CAS  PubMed  Google Scholar 

  16. A. Piccolo, S. Nardi, and G. Concheri, Eur. J. Soil Sci., 47(3), 319 – 328 (1996).

    Article  CAS  Google Scholar 

  17. P. Conte and A. Piccolo, Chemosphere, 38, No. 3, 517 – 528 (1999).

    Article  CAS  PubMed  Google Scholar 

  18. N. P. Avakumova, Izv. Samarsk. Nauchn. Tsentra Ross. Akad. Nauk, 11(1(2)), 197 – 201 (2009).

    Google Scholar 

  19. F. J. Stevenson, Humus Chemistry: Genesis, Composition, Reactions, John, Wiley & Sons, New York (1994).

    Google Scholar 

  20. D. S. Orlov, Humous Soil Acids [in Russian], Moscow State University Press, Moscow (1974).

    Google Scholar 

  21. I. V. Perminova and D. M. Zhilin, Green Chemistry in Russia [in Russian], Moscow University Press, Moscow (2004), pp. 146 – 162; http://www.humate-sakhalin.ru/img/documents/2.pdf.

  22. M. V. Belousov, R. R. Akhmedzhanov, M. V. Zykova, et al., Khim.-Farm. Zh., 48(2), 29 – 31 (2014); Pharm. Chem. J., 48(2), 29 – 31 (2014); Pharm. Chem. J., 48(2), 97 – 99 (2014).

  23. S. De Angelis Curtis, R. Curuni, A. Fraioli, et al., Nephron, 81, Supplement 1, 98 – 102 (1999).

    Article  PubMed  Google Scholar 

  24. V. Bellizzi, L. De Nicola, R. Minutolo, et al., Nephron, 81, Supplement 1, 66 – 70 (1999).

    Article  CAS  PubMed  Google Scholar 

  25. F. Di Silverio, G. P. Ricciuti, A. R. D’Angelo, et al., Eur. Urol., 37(2), 145 – 148 (2000).

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. A. N. Nesmeyanov Institute of Elemental-Organic Compounds, Russian Academy of Sciences, 28 Vavilov Street, 11991, Moscow, Russia

    N. K. Davydova & V. N. Sergeev

  2. ECOS ITALIA, 9 Gorizia Street, Fiuggi (Frosinone), 03014, Italy

    E. Girbul

Authors
  1. N. K. Davydova
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  2. V. N. Sergeev
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  3. E. Girbul
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Correspondence to N. K. Davydova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 48, No. 9, pp. 25 – 30, September, 2014.

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Davydova, N.K., Sergeev, V.N. & Girbul, E. The Role of Humous Acids in Acqua di Fiuggi Mineral Water in Degrading Stones Formed in the Urinary Tract (Review). Pharm Chem J 48, 587–592 (2014). https://doi.org/10.1007/s11094-014-1155-y

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  • DOI: https://doi.org/10.1007/s11094-014-1155-y

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