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Quantative Determination of the New Glutamic Acid Derivative Glutaron in Biological Samples

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Pharmaceutical Chemistry Journal Aims and scope

An HPLC method for quantitative determination of glutaron was developed in order to perform a pharmacokinetic analysis. The method was highly sensitive and selective and could be used for determination in biological samples. The sample preparation method was optimized and did not significantly affect the average measurement error of the HPLC quantitative determination.

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References

  1. V. V. Bagmetova, Yu. V. Chernysheva, O. V. Merkushenkova, et al., Eksp. Klin. Farmakol., 76(3), 7 – 9 (2013).

    CAS  Google Scholar 

  2. A. A. Spasov, L. A. Smirnova, I. N. Iezhitsa, et al., Vopr. Med. Khim., 48(3), 233 – 258 (2002).

    PubMed  CAS  Google Scholar 

  3. I. N. Tyurenkov, V. N. Perfilova, L. A. Smirnova, et al., Khim.-farm. Zh., 44(12), 68 – 70 (2010); Pharm. Chem. J., 44(12), 702 – 704 (2011).

  4. I. N. Tyurenkov, V. N. Perfilova, L. A. Smirnova, et al., Khim.-farm. Zh., 47(3), 55 – 56 (2013); Pharm. Chem. J., 47(3), 179 – 180 (2013).

  5. Guideline on Bioanalytical Method Validation (EMEA 2012); www.ema.europa.eu [http://www.ema.europa.eu/docs/enGB/documentlibrary/Scientificguideline/2011/08/WC500109686.pdf].

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 48, No. 6, pp. 54 – 56, June, 2014.

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Smirnova, L.A., Ryabukha, A.F., Kuznetsov, K.A. et al. Quantative Determination of the New Glutamic Acid Derivative Glutaron in Biological Samples. Pharm Chem J 48, 414–416 (2014). https://doi.org/10.1007/s11094-014-1122-7

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  • DOI: https://doi.org/10.1007/s11094-014-1122-7

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