Skip to main content
SpringerLink
Log in

Quantitative Determination of the Peptide GB-115 in Biological Media by HPLC/MS

  • Structure of Chemical Compounds, Methods of Analysis and Process Control
  • Published:
Pharmaceutical Chemistry Journal Aims and scope

A chromatographic method for quantitative determination of the peptide substance GB-115 with anxiolytic activity was developed. The optimum conditions for GB-115 extraction from biological materials were found. Quantitative determination was carried out using HPLC with mass-spectrometric detection. The detection limit of GB-115 was 1 ng/mL.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. T. A. Gudasheva, E. P. Kir’yanova, L. G. Kolik, et al., Bioorg. Khim., 33(4), 413 – 420 (2007).

    PubMed  CAS  Google Scholar 

  2. S. S. Boiko, G. B. Kolyvanov, V. P. Zherdev, et al., Byull. Eksp. Biol. Med., 144(9), 285 – 287 (2007).

    Google Scholar 

  3. A. S. Sorokina, S. V. Alekseeva, E. P. Nemova, et al., Eksp. Klin. Farmakol., 73(6), 29 – 32 (2010).

    PubMed  CAS  Google Scholar 

  4. L. G. Kolik, T. A. Gudasheva, and S. B. Seredenin, Byull. Eksp. Biol. Med., 135(5), 519 – 523 (2003).

    Article  Google Scholar 

  5. L. G. Kolik, T. L. Garibova, S. A. Litvinova, et al., Vestn. Ross. Akad. Med. Nauk, No. 7, 37 – 41 (2011).

Download references

Author information

Authors and Affiliations

  1. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, 125315, Russia

    E. V. Ivannikova, S. S. Boiko, D. V. Bastrygin, V. P. Zherdev & T. A. Gudasheva

Authors
  1. E. V. Ivannikova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. S. Boiko
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. V. Bastrygin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. V. P. Zherdev
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. T. A. Gudasheva
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to E. V. Ivannikova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 47, No. 9, pp. 35 – 38, September, 2013.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ivannikova, E.V., Boiko, S.S., Bastrygin, D.V. et al. Quantitative Determination of the Peptide GB-115 in Biological Media by HPLC/MS. Pharm Chem J 47, 321–324 (2013). https://doi.org/10.1007/s11094-013-0953-y

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-013-0953-y

Keywords

Search

Navigation