The technology of solid-state modification of hyaluronic acid (HA) with sodium decahydroborate by deformation in Bridgman anvils was developed. The deformation was carried out at a pressure of 1 GPa and a rotation angle of 500°. The structure of the obtained complexes was studied. It was shown using Raman and IR-Fourier spectroscopy that HA and the polyborates could form a network of cyclic polymeric chelate complexes in which HA acted as a multidentate ligand. The biodistribution of the HA-based B-containing compound in organs and tissues of mice with B-16 melanoma was studied after a single intratumoral administration. The maximum B content in the tumor was observed 15 min after administration. However, it was halved after 1 h and decreased by 5 times by 3 h. The most opportune time for performing a boron-neutron-capture therapy session was 30 min after administration when the tumor B concentration was >30 μg/g and exceeded the content in surrounding tissues. The tumor/muscle and tumor/blood ratios reached 3 and 5, respectively. Use of this non-toxic compound for neutron-capture therapy was deemed promising based on preclinical studies.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 47, No. 6, pp. 14 – 18, June, 2013.
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Koryakin, S.N., Ivanov, P.L., Khabarov, V.N. et al. Synthesis and Use of Hyaluronic Acid–10B Polymeric Chelates for Neutron-Capture Therapy. Pharm Chem J 47, 299–302 (2013). https://doi.org/10.1007/s11094-013-0947-9
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DOI: https://doi.org/10.1007/s11094-013-0947-9