The effects of solid dispersions (SDs) on furacilin solubility were studied. Furacilin and its SDs with polyethyleneglycol-1500 (PEG) and polyvinylpyrrolidone-10000 (PVP) were investigated. SD formation doubled furacilin solubility and increased its dissolution rate as the SD with PVP by 12 times compared with furacilin powder. It was supposed that several factors were responsible for the improved release of furacilin from the SD. These included reduced crystallinity, amorphization, and intermolecular interactions, presumably H-bonds.
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References
R. U. Khabriev, V. G. Kukes, A. P. Arzamastsev, et al. (eds.), Antibacterial Drugs. Methods of Standardizing Preparations [in Russian], Meditsina, Moscow (2004), pp. 94 – 101.
M. D. Mashkovskii, Drugs [in Russian], RIA Novaya Volna, Moscow (2007), pp. 76 – 77.
V. A. Popkov, V. Yu. Reshetnyak, I. I. Krasnyuk, Jr., et al., Farmatsiya, 3, 39 – 42 (2005).
Yu. V. Skovpen’, Author's Abstract of a Candidate Dissertation in Pharmaceutical Sciences, Moscow (2002).
I. I. Krasnyuk, Author's Abstract of a Candidate Dissertation in Pharmaceutical Sciences, Moscow (2003).
I. I. Krasnyuk, Jr., V. A. Popkov, V. Yu. Reshetnyak, et al., Ross. Med. Zh., No. 6, 34 – 37 (2005).
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Translated from Khimiko-farmatsevticheskii Zhurnal, Vol. 46, No. 12, pp. 49–52, December, 2012.
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Nikulina, O.I., Krasnyuk, I.I., Belyatskaya, A.V. et al. Furacilin Release from Solid Dispersions. Pharm Chem J 46, 745–749 (2013). https://doi.org/10.1007/s11094-013-0884-7
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DOI: https://doi.org/10.1007/s11094-013-0884-7