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Effect of Solid Dispersions with Polyethylene Glycol 1500 on the Solubility of Indomethacin

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Pharmaceutical Chemistry Journal Aims and scope

Solid dispersions (SDs) of indomethacin with polyethylene glycol 1500 (PEG-1500) were studied to determine their effect on indomethacin solubility. Production of SDs increased the solubility and dissolution rate of indomethacin in H2O. The solubility and dissolution rate of indomethacin from SDs increased by 1.8 – 2.2 and 3.1 – 4.4 times, respectively. Indomethacin became less crystalline and then amorphous during preparation of the SDs. Dissolution of the SDs solubilized indomethacin and formed colloidal solutions.

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Authors and Affiliations

  1. I. M. Sechenov First Moscow State Medical University, 8/2 Trubetskaya St., Moscow, 119991, Russia

    I. I. Krasnyuk Jr, T. M. Kosheleva, A. V. Belyatskaya, I. I. Krasnyuk, O. I. Stepanova, V. V. Grikh & L. V. Ovsyannikova

  2. Rancho BioSciences, 16955 Via Del Campo Suite 220, San Diego, CA, 92127, USA

    Yu. Skovpen

Authors
  1. I. I. Krasnyuk Jr
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  2. T. M. Kosheleva
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  3. A. V. Belyatskaya
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  4. I. I. Krasnyuk
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  5. O. I. Stepanova
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  6. Yu. Skovpen
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  7. V. V. Grikh
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  8. L. V. Ovsyannikova
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Corresponding author

Correspondence to I. I. Krasnyuk.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 3, pp. 46 – 49, March, 2018.

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Krasnyuk, I.I., Kosheleva, T.M., Belyatskaya, A.V. et al. Effect of Solid Dispersions with Polyethylene Glycol 1500 on the Solubility of Indomethacin. Pharm Chem J 52, 241–244 (2018). https://doi.org/10.1007/s11094-018-1799-0

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  • DOI: https://doi.org/10.1007/s11094-018-1799-0

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