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Development and Validation of an LC/MS Method for Quantitative Determination of Thiamine in Blood Plasma

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A new sensitive method based on liquid chromatography with mass-spectrometric detection (LC/MS) was developed and validated for the quantitative determination of thiamine in blood plasma. The method is highly sensitive and selective due to the combination of LC and MS and can be used for determining the thiamine blood concentration during pharmacokinetic investigations.

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Authors and Affiliations

  1. Sechenov First Moscow State Medical University, Moscow, 119991, Russia

    O. A. Tashirova, G. V. Ramenskaya & A. M. Vlasov

  2. Institute of Immunology, Federal Medico-Biological Agency, Ministry of the Russian Federation for Public Health, Moscow, 115478, Russia

    O. A. Tashirova & M. R. Khaitov

Authors
  1. O. A. Tashirova
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  2. G. V. Ramenskaya
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  3. A. M. Vlasov
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  4. M. R. Khaitov
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Additional information

Translated from Khimiko-farmatsevticheskii Zhurnal, Vol. 46, No. 12, pp. 46–48, December, 2012.

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Tashirova, O.A., Ramenskaya, G.V., Vlasov, A.M. et al. Development and Validation of an LC/MS Method for Quantitative Determination of Thiamine in Blood Plasma. Pharm Chem J 46, 742–744 (2013). https://doi.org/10.1007/s11094-013-0883-8

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  • DOI: https://doi.org/10.1007/s11094-013-0883-8

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