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Trecrezan: Inhibitor of acid cholesterol esterase synthesis in platelets and monocytes

  • MOLECULAR-BIOLOGICAL PROBLEMS OF DRUG DESIGN AND MECHANISM OF DRUG ACTION
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Pharmaceutical Chemistry Journal Aims and scope

It was established that application of the domestic preparation trecrezan for the treatment of experimental atherosclerosis in rabbits led to decreases in the levels of cholesterol and total lipids in platelets (Tc) and monocytes (Mc) of the blood. Results of enzymatic analysis indicated that the development of atherosclerosis was accompanied by increased activity of acid cholesterol esterase by 64% in Mc and 22.7% in Tc compared to a standard. Intramuscular administration of trecrezan (25 mg/kg) reduced significantly the activity of acid cholesterol esterase by 35% in Mc and 26% in Tc compared with a control.

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References

  1. M. I. Dushkin, Byull. Sib. Otd. Ross. Akad. Med. Nauk, 120(2), 47 – 55 (2006).

    Google Scholar 

  2. N. Shibata and C. K. Glass, J. Lipid Res., 50, 277 – 281 (2009).

    Article  Google Scholar 

  3. A. V. Vasil’ev, E. A. Varsanovich, A. V. Pogozheva, et al., Vopr. Med. Khim., No. 5, 27 – 29 (1992).

  4. G. L. Starova, O. V. Frank-Kamenetskaya, V. S. Fundamenskii, et al., Dokl. Akad. Nauk SSSR, 260(4), 888 – 892 (1981).

    CAS  Google Scholar 

  5. M. G. Voronkov, M. K. Nurbekov, M. M. Rasulov, et al., Dokl. Ross. Akad. Nauk, 431(2), 261 – 264 (2010).

    Google Scholar 

  6. F. Gmelig-Meyling and T. A. Waldman, J. Immunol. Methods, 33, 1 – 9 (1980).

    Article  PubMed  CAS  Google Scholar 

  7. R. C. Pittman, J. C. Khao, and D. Steinberg, J. Biol. Chem., 250, 4505 – 4510 (1975).

    PubMed  CAS  Google Scholar 

  8. D. J. Severson and T. Fletcher, Atherosclerosis, 31, 21 – 32 (1978).

    Article  PubMed  CAS  Google Scholar 

  9. M. M. Rasulov, I. G. Kuznetsov, M. V. Velikaya, et al., Dokl. Akad. Nauk SSSR, 310(5), 1256 – 1259 (1990).

    PubMed  CAS  Google Scholar 

  10. V. A. Nagornev, Med. Akad. Zh., 5(3), 121 – 133 (2005).

    Google Scholar 

  11. R. R. Packard and P. Libby, Clin. Chem., 54(1), 24 – 38 (2008).

    Article  PubMed  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Moscow State Pedagogical University, Moscow, Russia

    M. M. Rasulov, S. N. Bobkova, O. A. Belikova, M. K. Nurbekov, N. P. Shimanovskaya & L. K. Karaulova

  2. Favorsky Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, Irkutsk, Russia

    M. G. Voronkov

Authors
  1. M. M. Rasulov
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  2. S. N. Bobkova
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  3. O. A. Belikova
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  4. M. K. Nurbekov
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  5. N. P. Shimanovskaya
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  6. L. K. Karaulova
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  7. M. G. Voronkov
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 46, No. 9, pp. 3 – 5, September, 2012.

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Rasulov, M.M., Bobkova, S.N., Belikova, O.A. et al. Trecrezan: Inhibitor of acid cholesterol esterase synthesis in platelets and monocytes. Pharm Chem J 46, 523–525 (2012). https://doi.org/10.1007/s11094-012-0838-5

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  • DOI: https://doi.org/10.1007/s11094-012-0838-5

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