Phylloclades of Ruscus colchicus P. F. Yeo turned out to be a rich source of steroidal glycosides with the biosynthesis of up to 40 steroids. A total of 22 pure compounds were isolated and identified including 1 cholestanol, 17 furostanol, and 4 spirostanol glycosides, among which 16 appeared to be novel organic compounds. Attention was drawn to the high number of sulfated compounds including six furostanols, two spirostanols, and one cholestanol. A pharmacological investigation showed that an aqueous EtOH extract of R. colchicus leaves exhibited pronounced lactogenic action.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 46, No. 6, pp. 45 – 48, June, 2012.
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Kemertelidze, E.P., Muzashvili, T.S., Benidze, M.M. et al. Chemical composition and pharmacological activity of Ruscus colchicus leaves. Pharm Chem J 46, 372–375 (2012). https://doi.org/10.1007/s11094-012-0801-5
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DOI: https://doi.org/10.1007/s11094-012-0801-5