Crystallization of pharmaceutical substance venlafaxine was studied. The purity of the recrystallized product was established by elemental analysis, differential scanning calorimetry (DSC), HPLC, and IR and NMR spectroscopy.
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Acknowledgments
The work was supported financially by the DCSM, RAS, No. 90-DCSM “Bioorganic Medicinal Chemistry” and the RAS Presidium No. P-5 “Fundamental Sciences – Medicine”. We thank Cand. Chem. Sci. G. G. Ivanova (IOEC, RAS) for performing the chromatographic analysis; Cand. Chem. Sci. A. L. Nikolaev (Lomonosov MSU) for particlesize analysis by photomicrography; and Scientist E. P. Kharitonova (Lomonosov MSU) for the thermal analysis.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 46, No. 1, pp. 45 – 48, January, 2012.
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Galkina, M.A., Galkin, O.M. & Kochetkov, K.A. Crystallization and quality examination of pharmaceutical substance venlafaxine. Pharm Chem J 46, 60–63 (2012). https://doi.org/10.1007/s11094-012-0734-z
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DOI: https://doi.org/10.1007/s11094-012-0734-z