Skip to main content

Advertisement

SpringerLink
Log in

Kinetics of piroxicam release from low-methylated pectin/zein hydrogel microspheres

  • Published:
Pharmaceutical Chemistry Journal Aims and scope

The kinetics of a model drug (piroxicam) release from pectin/zein hydrogel microspheres was studied under conditions simulating the gastrointestinal tract. It is established that the rate-limiting step in the release mechanism is drug diffusion out of the microspheres rather than its dissolution. The results demonstrate the effectiveness of using this system based on hydrogel microspheres as a sustained drug delivery system capable of prolonging drug release for a period of 36 h and more with allowance for diffusion and enzymatic biodegradation in the hydrogel.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. W. Landgraf, N.-H. Li, and J. R. Benson, Drug Delivery Technol., 3(1), 1 – 12 (2003).

    Google Scholar 

  2. M. Grassi and G. Grassi, Matrix Syst. Curr. Drug Del., 2(1), 97 – 116 (2005).

    Article  CAS  Google Scholar 

  3. C. C. Lin and A. T. Metters, Adv. Drug Delivery Rev., 58, 1379 – 1408 (2006).

    Article  CAS  Google Scholar 

  4. Z. K. Mukhidinov, G. F. Kasymova, D. T. Bobokalonov, et al., Khim.-farm. Zh., 44(10), 35 – 39 (2010).

    Google Scholar 

  5. A. M. Lowman and N. A. Peppas, in: Encyclopedia of Controlled Drug Delivery, E. Mathiowitz (ed.), Wiley, New York (1999), Vol. 1, p. 397.

    Google Scholar 

  6. V. Pillay, M. P. Danckwerts, Z. K. Muhydinov, and R. Fassihi, Drug Dev. Ind. Pharm., 31, 191 – 207 (2005).

    Article  PubMed  CAS  Google Scholar 

  7. N. A. Peppas, et al., Adv. Drug Delivery Rev., 48, 137 – 138 (2001).

    Article  Google Scholar 

  8. P. L. Ritger and N. A. Peppas, J. Controlled Release, 5, 23 – 36 (1987).

    Article  CAS  Google Scholar 

  9. G. F. Kasimova, Z. K. Muhidinov, A. Sh. Shtanchaev, et al., Int. Conference Nanostructures in Polysaccharides, Tashkent, Uzbekistan (2008), pp. 61 – 63.

Download references

Author information

Authors and Affiliations

  1. Nikitin Institute of Chemistry, Tajik Academy of Sciences, Dushanbe, Republic of Tajikistan

    J. T. Bobokalonov, G. F. Kasimova, Z. K. Muhidinov, A. S. Jonmurodov & D. Kh. Khalikov

  2. Eastern Regional Research Center, U. S. Department of Agriculture, Philadelphia, USA

    LinShu Liu

Authors
  1. J. T. Bobokalonov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. F. Kasimova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Z. K. Muhidinov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. S. Jonmurodov
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. D. Kh. Khalikov
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. LinShu Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 46, No. 1, pp. 34 – 37, January, 2012.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bobokalonov, J.T., Kasimova, G.F., Muhidinov, Z.K. et al. Kinetics of piroxicam release from low-methylated pectin/zein hydrogel microspheres. Pharm Chem J 46, 50–53 (2012). https://doi.org/10.1007/s11094-012-0732-1

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-012-0732-1

Key words

Search

Navigation