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Interpolymer interaction between countercharged types of Eudragit® RL30D and FS30D in binary films as a method of drug release modification in oral delivery systems

  • DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY
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Pharmaceutical Chemistry Journal Aims and scope

Interpolymer interaction between countercharged copolymers Eudragit® RL30D (polycation) and Eudragit® FS30D (polyanion) was studied under simulated gastrointestinal tract conditions using FT-IR spectroscopy and modulated-temperature differential scanning calorimetry (MT-DSC) in order to find a mechanism for modifying diclofenac sodium release from an oral matrix delivery system.

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Authors and Affiliations

  1. Kazan State Medical University, Kazan, Tatarstan, Russia

    R. I. Mustafin & A. V. Bodrov

  2. Scientific Center for Biomedical Technologies, State Research Institute of Medicinal and Aromatic Plants, Moscow, Russia

    V. A. Kemenova

  3. Leuven Catholic University, Leuven, Belgium

    P. Rombaut & G. Van den Mooter

Authors
  1. R. I. Mustafin
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  2. A. V. Bodrov
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  3. V. A. Kemenova
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  4. P. Rombaut
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  5. G. Van den Mooter
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 46, No. 1, pp. 29 – 33, January, 2012.

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Mustafin, R.I., Bodrov, A.V., Kemenova, V.A. et al. Interpolymer interaction between countercharged types of Eudragit® RL30D and FS30D in binary films as a method of drug release modification in oral delivery systems. Pharm Chem J 46, 45–49 (2012). https://doi.org/10.1007/s11094-012-0731-2

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  • DOI: https://doi.org/10.1007/s11094-012-0731-2

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