GB-115 is an original peptide anxiolytic with the structure N-(6-phenylhexanoyl)glycyl-L-tryptophan amide that has been developed at Zakusov State Institute of Pharmacology (Moscow). The physicochemical properties of GB-115 parent substance were studied. Analytical procedures for it were elaborated. General pharmacopoeial quality characteristics have been determined. UV, IR, and NMR spectra have been measured. A method for determining foreign impurities in GB-115 parent substance that is based on HPLC was developed.
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References
Yu. A. Aleksandrovskii, Border-line Psychic Disorders [in Russian], Moscow (2000).
J. G. Edwards, Drugs, 22, 495–514 (1981).
L. G. Kolik, T. A. Gudasheva, and S. B. Seredenin, Byul. Eksp. Biol. Med., 135(5), 519–523 (2003).
L. G. Kolik, V. N. Zhukov, and S. B. Seredenin, Byul. Eksp. Biol. Med., 70(2), 8–11 (2007).
E. V. Shipaeva, L. P. Kovalenko, S. Khaidukov, et al., Byul. Eksp. Biol. Med., 145(5), 548–51 (2008).
A. V. Sorokina, S. V. Alekseeva, E. P. Nemova, et al., Byul. Eksp. Biol. Med., 73(6), 29–32 (2010).
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 45, No. 10, pp. 53 – 56, October, 2011.
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Klumova, V.S., Grushevskaya, L.N., Avdyunina, N.I. et al. Physicochemical properties of and analytical method for the original anxiolytic substance GB-115. Pharm Chem J 45, 646–649 (2012). https://doi.org/10.1007/s11094-012-0695-2
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DOI: https://doi.org/10.1007/s11094-012-0695-2