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Synthesis and antibacterial and antifungal properties of 2-thiocyanato-(2-methyl)-3-arylpropionamides and 2-amino-5-benzyl-(5-methyl)thiazol-4-ones

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Pharmaceutical Chemistry Journal Aims and scope

A series of 2-thiocyanato-(2-methyl)-3-arylpropionamides and products of their heterocyclization, 2-amino-5-benzyl-(5-methyl)thiazol-4-ones, have been synthesized. The synthesized compounds exhibit rather high antibacterial activity with respect to strains of staphylococci, intestinal rods, aerobic bacilli, and yeast fungi. The majority of these compounds show a clearly expressed anti-candidiasis effect.

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Authors and Affiliations

  1. Hnatyuk Ternopil National Pedagogical University, Ternopil, Ukraine

    B. D. Grishchuk & V. S. Baranovskii

  2. Horbachevsky Ternopil State Medical University, Ternopil, Ukraine

    S. I. Klimnyuk

Authors
  1. B. D. Grishchuk
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  2. V. S. Baranovskii
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  3. S. I. Klimnyuk
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 45, No. 9, pp. 18–21, September, 2011.

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Grishchuk, B.D., Baranovskii, V.S. & Klimnyuk, S.I. Synthesis and antibacterial and antifungal properties of 2-thiocyanato-(2-methyl)-3-arylpropionamides and 2-amino-5-benzyl-(5-methyl)thiazol-4-ones. Pharm Chem J 45, 532–535 (2011). https://doi.org/10.1007/s11094-011-0673-0

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  • DOI: https://doi.org/10.1007/s11094-011-0673-0

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