A series of new spiro-condensed indoles have been synthesized and the relationship between their chemical structure and biological activity has been established. Reduction of the oxo group in previously synthesized hydrochlorides of 2′-oxyindolin(5′-bromoindolin)-3?-spiro-1-(1,2,3,4-tetrahydro-β-carboline and 3-methyl-β-carboline followed by treatment with an ether solution of HCl leads to the dihydrochlorides of indolin-(5′-bromoindolin)-3′-spiro-1-(1,2,3,4-tetrahydro-β-carboline and 3-methyl-β-carboline.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 45, No. 8, pp. 20 – 21, August, 2011.
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Pogosyan, S.A., Grigoryan, N.P. & Paronikyan, R.G. Synthesis and anticonvulsant activity of indolin(5′-bromoindolin)-3′-spiro-1-(1,2,3,4-tetrahydro)-β-carboline and 3-methyl-β-carboline dihydrochlorides. Pharm Chem J 45, 466–467 (2011). https://doi.org/10.1007/s11094-011-0656-1
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DOI: https://doi.org/10.1007/s11094-011-0656-1