New 2-S-4,5,6-substituted pyrimidines have been prepared via the reaction of 2-mercaptopyrimidines with allyl-, methallyl-, and substituted-benzyl chlorides, chloroacetamide, and chloracetic, á-bromopropionic, and á-bromocaproic acids. Reactions of 2-methylthio-derivatives with morpholine, piperidine, and o- and p-anisidines yielded the corresponding 2-amino-derivatives. The antitumor properties of the synthesized compounds have been studied.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 45, No. 3, pp. 9 – 12, March, 2011.
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Grigoryan, L.A., Kaldrikyan, M.A., Melik-Ogandzhanyan, R.G. et al. Synthesis and antitumor activity of new 2-thioand 2-amino-substituted pyrimidines. Pharm Chem J 45, 137–140 (2011). https://doi.org/10.1007/s11094-011-0576-0
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DOI: https://doi.org/10.1007/s11094-011-0576-0