Cyclization of substituted thiosemicarbazides in alkaline medium was used to synthesize the corresponding 3-thio-4-benzyl(cyclohexyl, allyl)-5-(4-benzyloxyphenyl)-1,2,4-triazoles. These compounds were 3-S-alkylated with ethylene chlorohydrin, chloroacetamide, 3-bromo-4-methoxybenzyl chloride, and chloroacetic, 2-bromopropionic, and 2-bromocaproic acids. Aminomethylation and oxymethylation reactions were studied. 2-N-Aminomethylene and 2-N-oxymethylenetriazoline-3-thiones were prepared. The antitumor activity of the compounds synthesized here were studied.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 51, No. 9, pp. 12 – 14, September, 2017.
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Kaldrikyan, M.A., Melik-Ohanjanyan, R.G. & Arsenyan, F.H. Synthesis and Antitumor Activity of 2-N-,3-S-Substituted 5-(4-Benzyloxyphenyl)-1,2,4-Triazoles. Pharm Chem J 51, 760–763 (2017). https://doi.org/10.1007/s11094-017-1688-y
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DOI: https://doi.org/10.1007/s11094-017-1688-y