Tropane derivatives have been synthesized with the aim of finding serotonin antagonists with potential antimigraine activity. Aromatic and heteroaromatic esters of tropan-3-oxime were obtained. Their cerebrovascular activity as manifested by antiserotonin properties has been studied. On this basis the new antimigraine drug tropoxin has been discovered.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 44, No. 9, pp.6–9, September, 2010.
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Kostochka, L.M., Gan’shina, T.S., Mirzoyan, R.S. et al. Synthesis and antiserotoninergic activity of new tropane derivatives. Pharm Chem J 44, 472–475 (2010). https://doi.org/10.1007/s11094-010-0494-6
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DOI: https://doi.org/10.1007/s11094-010-0494-6