The effect of solid dispersion (SD) formation on the solubility of the antibiotic erythromycin has been studied using the parent substance of erythromycin and its SDs with polyethyleneglycol (PEG-1500), polyvinylpyrrolidone (PVP-10000), and β-cyclodextrin. It is established that SD formation increases the solubility of the antibiotic by a factor of 1.3 – 1.8; the dissolution rate, 1.5 – 2.0. Results using a complex of physical and chemical methods suggest that the increase in erythromycin release from SDs takes place due to a decrease in the degree of crystallinity and the formation of intermolecular complexes.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 43, No. 11, pp. 36 – 43, November, 2009.
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Khabriev, R.U., Popkov, V.A., Reshetnyak, V.Y. et al. Solubility of erythromycin from solid dispersions. Pharm Chem J 43, 625–631 (2009). https://doi.org/10.1007/s11094-010-0367-z
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DOI: https://doi.org/10.1007/s11094-010-0367-z