N1-linked conjugates of eremomycin with 1-adamantylacetic and p-(1-adamantyl)phenoxyacetic acids were synthesized for the first time. Their activity against herpes simplex virus 2 (HSV-2) was demonstrated (SI ∼ 10). At the same time, modification of the N-methylleucine fragment of eremomycin with adamantanecarboxylic acids led to some decrease in antibacterial activity.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 43, No. 9, pp. 3 – 8, September, 2009.
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Kovalev, V.V., Alimbarova, L.M., Shokova, E.A. et al. Synthesis, antiherpes, and antibacterial activity of N-linked conjugates of eremomycin with adamantanecarboxylic acids. Pharm Chem J 43, 485–490 (2009). https://doi.org/10.1007/s11094-009-0342-8
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DOI: https://doi.org/10.1007/s11094-009-0342-8