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Synthesis, antibacterial and antifungal activity of 1, 3-di(2-substituted 10H-phenothiazin-10-yl)propan-1-one

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Pharmaceutical Chemistry Journal Aims and scope

Aseries of 1,3-di(2-substituted 10H-phenothiazin-10-yl)propan-1-one (IVa – p) was synthesized by using the phenothiazine framework through a three-carbon atom chain by condensation of the different chlorides of 3-(10H-phenothiazin-10-y1)propionic acid (IIIa – d) with 2- substituted phenothiazines (Ia – d), and the structures of these compounds were confirmed by IR, 1H NMR, mass, and elemental analysis. The newly synthesized compounds were evaluated for antimicrobial activity.

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References

  1. M. K. El-Said, Pharmazie, 36, 678 – 679 (1981).

    CAS  Google Scholar 

  2. S. R. Tilak, R. Tyagi, B. Goel, and K. K. Saxena, Indian Drugs, 35, 221 – 227(1998).

    Google Scholar 

  3. J. N. Dominguez, S. Lopez, J. Charris, et al., J. Med. Chem., 40, 2726 – 2733 (1997)

    Article  CAS  PubMed  Google Scholar 

  4. G. Lin, K. K. Midha, and E. M. Hawes, J. Heterocycl. Chem., 28, 215 – 219 (1991).

    CAS  Google Scholar 

  5. J. Raval and K. K. Desai, ARKIVOC, (XIII), 21 – 28 (2005).

    Google Scholar 

  6. M. Viveros and L. Amaral, Int. J. Antimicrob. Ag., 17, 225 – 228 (2001).

    Article  Google Scholar 

  7. L. Amaral and Kristiansen, Int. J. Antimicrob. Ag., 14, 173 – 180 (2000)

    Article  CAS  Google Scholar 

  8. A. Trivedi, A. Siddiqui, and V. Shah, ARKIVOC, (XII), 210 – 217 (2008).

    Google Scholar 

  9. N. Motohashi, M. Kawasa, S. Saito, and H. Sakagami, Curr. Drug Targets, 1, 237 – 240 (2000).

    Article  CAS  PubMed  Google Scholar 

  10. N. Motohashi, T. Kurihara, K. Satoh, et al., J. Anticancer Res., 19, 1837 – 1842 (1999).

    CAS  Google Scholar 

  11. T. Kurihara, N. Motohasho, G. L. Pang, et al., J. Anticancer Res., 16, 2757 – 2765 (1996).

    CAS  Google Scholar 

  12. D. Ledincer and L. A. Mitscher, The Organic Chemistry of Drug Synthesis, Wiley, New York (1976), Vol. 1, p. 372 – 392.

    Google Scholar 

  13. A. A. Borbely and M. Loepfe-Hinkkanen, Mod. Phamacol. Toxicol., 16, 403 – 426 (1979).

    CAS  Google Scholar 

  14. W. R. Reid, J. R. Wright, H. G. Kollofe, et al., J. Am. Chem. Soc., 70, 3100 – 3102 (1948).

    Article  CAS  PubMed  Google Scholar 

  15. I. Meiermed, Monatsh. Chem., 8, 397 – 399 (1954).

    Google Scholar 

  16. J. L. Vennerstrom, A. L. Ager, S. L. Andersen, et al., J. Med. Chem., 41, 4360 – 4367 (1998).

    Article  CAS  PubMed  Google Scholar 

  17. B. C. May, A. T. Fafarman, S. B. Hong, et al., Proc. Natl. Acad. Sci. U. S. A., 100, 3416 – 3421 (2003).

    Article  CAS  PubMed  Google Scholar 

  18. X. L. Smith, J. Org. Chem., 15, 1129 – 1130 (1950).

    Google Scholar 

  19. R. Cruickshank, J. P. Duguid, B. P. Marion, et al., Medicinal Microbiology. 12th ed., Churchill Livingstone, London (1975), Vol. II, p. 196 – 202.

  20. A. H. Collins (ed.), Microbiological Methods, 2nd ed., Butterworth, London (1976).

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Authors and Affiliations

  1. Department of Chemistry, University of Mumbai, Vidyanagari, Kalina, Santacruz (East), Mumbai, 400 098, India

    T. N. Bansode & V. G. Dongre

  2. Department of Biophysics, University of Mumbai, Vidyanagari, Kalina, Santacruz (East), Mumbai, 400 098, India

    P. M. Dongre

Authors
  1. T. N. Bansode
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  2. P. M. Dongre
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  3. V. G. Dongre
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Correspondence to V. G. Dongre.

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Bansode, T.N., Dongre, P.M. & Dongre, V.G. Synthesis, antibacterial and antifungal activity of 1, 3-di(2-substituted 10H-phenothiazin-10-yl)propan-1-one. Pharm Chem J 43, 311–314 (2009). https://doi.org/10.1007/s11094-009-0297-9

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  • DOI: https://doi.org/10.1007/s11094-009-0297-9

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