The effects of solid dispersions (SD) on the solubility of antibiotics were studied. Rifampicin, amoxycillin trihydrate and their SD with polyethylene glycol 1500, polyvinylpyrrolidone 10,000, and β-cyclodextrin were investigated. Preparation of SD increased the solubility and rate of dissolution of antibiotics. The solubility of rifampicin from SD increased by a factor of 2 – 2.7. The rate of dissolution from SD increased by factors o 2 – 2.7. Previous studies using a variety of physicochemical study methods have suggested that improvements in antibiotic release from SD occur as a result of decreases in crystallinity and the formation of intermolecular complexes.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 43, No. 4, pp. 48 – 50, April, 2009.
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Krasnyuk, I.I. Effects of solid dispersions on the solubility of antibiotics. Pharm Chem J 43, 226–229 (2009). https://doi.org/10.1007/s11094-009-0267-2
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DOI: https://doi.org/10.1007/s11094-009-0267-2