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In vitro tocolytic activity of 3-benzamido-1-(4-(2-methoxyphenyl)-piperazin-1-yl)-propyl-2-isopropylcarboxamide

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The synthesis of 3-benzamido-1-(4-(2-methoxyphenyl) piperazin-1-yl)-propyl-2-isopropylcarboxamide (BPC) was accomplished by treating N-3-(4-(2-methoxyphenyl)piperazin-1-yl)-propyl-2-isopropylphthalimide with isopropylamine in dimethylformamide at room temperature. The compound was characterized spectroscopically. At concentrations of 0.05 and 0.1 mg/ml, 3-benzamido-1-(4-(2-methoxyphenyl)piperazin-1-yl)-propyl-2-isopropylcarboxamide (BPC) produced a significant inhibition of oxytocin (p < 0.05) and acetylcholine (p < 0.0001) induced contractions of the uterine smooth muscle in non-pregnant rats in a dose-dependent manner. From the results obtained it may be inferred that this compound is probably acting via muscarinic receptors.

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Authors and Affiliations

  1. Departments of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, Nigeria

    Okunrobo O. Lucky

  2. Departments of Pharmacology and Toxicology, Faculty of Pharmacy, University of Benin, Benin City, Nigeria

    Owolabi J. Omonkhelin

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  1. Okunrobo O. Lucky
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  2. Owolabi J. Omonkhelin
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Correspondence to Okunrobo O. Lucky.

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Lucky, O.O., Omonkhelin, O.J. In vitro tocolytic activity of 3-benzamido-1-(4-(2-methoxyphenyl)-piperazin-1-yl)-propyl-2-isopropylcarboxamide. Pharm Chem J 43, 16–18 (2009). https://doi.org/10.1007/s11094-009-0237-8

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  • DOI: https://doi.org/10.1007/s11094-009-0237-8

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