Cholesterol and its esters with aliphatic acids were studies as agents increasing the transdermal penetration of phenazepam when given transdermally in mice. Drug penetration was measured in terms of its pharmacological action (anticonvulsive effect on intravenous administration of 1% corasole). These studies showed that of the compounds studied, cholesteryl pelargonate had the greatest enhancing effect.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
I. A. Kravchenko, Transdermal Administration of Drug [in Russian], Astroprint, Odessa (2001).
I. A. Kravchenko, S. A. Andronati, and V. B. Larionov, Physico-Chemical Bases of Enhancements in the Transdermal Administration of Drugs [in Russian], Astroprint, Odessa (2002).
I. A. Kravchenko, V. B. Larionov, A. I. Aleksandrova, et al., Khim.-Farm. Zh., 37, No. 7, 31–35 (2003).
N. Ya. Golovenko, V. G. Zin’kovskii, and E. A. Fedorova, Byull. Éksperim. Biol. Med., 123, No. 5, 551–554 (1997).
A. I. Hyalatina, L. G. Novikova, L. G. Derkach, et al., Mol. Cryst. Liq. Crys., 140, 11–81 (1986).
D. Demis, H. Demis, and H. Zaichke, Feussige Kristalle in Tabullen, Deutschter Verlag für Grundstoffindustrie, Leipzig (1974).
Author information
Authors and Affiliations
Additional information
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 43, No. 1, pp. 3–10, January, 2009.
Rights and permissions
About this article
Cite this article
Kravchenko, I.A., Novikova, N.S., Larionov, V.B. et al. Effects of cholesterol and its esters on transdermal penetration of phenazepam. Pharm Chem J 43, 1–3 (2009). https://doi.org/10.1007/s11094-009-0222-2
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11094-009-0222-2