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Complexes of dihydroquercetin with chromium (III) and zinc (II) asparaginates in water and their effects on the state of lecithin membranes

  • Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
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Pharmaceutical Chemistry Journal Aims and scope

The formation of chelate complexes of dihydroqercetin (DHQ) with zinc and chromium asparaginates in aqueous solution is established and their interaction with a lecithin monolayer is estimated. On the basis of analysis of the surface pressure-molecular area isotherms, it is concluded that an increase in the molecular area from 0.54 to 0.80–0.90 nm 2 is indicative of the immobilization of DHQ complexes in the lecithin monolayer. It is shown that the concentration of the initial products of lipid peroxidacion-diene and triene conjugates-decreases to 24 % and 41 %, respectively, and that of the final products (Schiff bases) in the blood of patients treated by Oftalvit (containing DHQ and metal asparaginates) decreases to 46 % in comparison to values in the control groups.

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Authors and Affiliations

  1. Universidad Michoacana de San Nicolas de Hidalgo, Morelia, Michoacan, Mexico

    L. G. Donracheva

  2. State Higher Professional Educational Institution Nizhegorod State Medical Academy, Russian Ministry of Health, Nizhnii Novgorod, Russia

    N. B. Mel’nikova, I. A. Pegova & A. A. Volkov

  3. G. A. Razuvaev Institute of Metallo-organic Chemistry, Russian Academy of Sciences, Nizhnii Novgorod, Russia

    G. A. Domrachev

  4. Semashko State Health Directorate, Nizhegorod Regional Clinical Hospital, Nizhnii Novgorod, Russia

    O. V. Kol’chik

Authors
  1. L. G. Donracheva
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  2. N. B. Mel’nikova
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  3. I. A. Pegova
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  4. A. A. Volkov
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  5. G. A. Domrachev
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  6. O. V. Kol’chik
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Corresponding author

Correspondence to N. B. Mel’nikova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 42, No. 10, pp. 14–20, October, 2008.

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Donracheva, L.G., Mel’nikova, N.B., Pegova, I.A. et al. Complexes of dihydroquercetin with chromium (III) and zinc (II) asparaginates in water and their effects on the state of lecithin membranes. Pharm Chem J 42, 564–570 (2008). https://doi.org/10.1007/s11094-009-0186-2

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  • DOI: https://doi.org/10.1007/s11094-009-0186-2

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