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Reaction of substituted o-aminophenols with acylpyruvic acid esters and α-ketoglutaric acid. Antibacterial activity of the products

  • Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
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Abstract

Reaction of methyl esters of acylpyruvic acids with substituted o-aminophenols led to 6(7)-substituted 3-acylmethylene-1,4-benzoxazin-2-ones. Reaction of substituted o-aminophenols with α-ketoglutaric acid led to 6-substituted 3-carbonyl-1,4-benzoxazin-2-ones. The structures of the synthesized compounds were confirmed by IR and NMR spectroscopy and mass spectrometry. The antibacterial activity of the compounds was studied.

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Authors and Affiliations

  1. Perm State Pharmaceutical Academy, Perm, Russia

    V. L. Gein, N. A. Rassudikhina, N. V. Shepelina, M. I. Vakhrin, E. B. Babushkina & E. V. Voronina

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  1. V. L. Gein
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  2. N. A. Rassudikhina
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  3. N. V. Shepelina
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  4. M. I. Vakhrin
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  5. E. B. Babushkina
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  6. E. V. Voronina
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 42, No. 9, pp. 34–36, September, 2008.

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Gein, V.L., Rassudikhina, N.A., Shepelina, N.V. et al. Reaction of substituted o-aminophenols with acylpyruvic acid esters and α-ketoglutaric acid. Antibacterial activity of the products. Pharm Chem J 42, 529–532 (2008). https://doi.org/10.1007/s11094-009-0175-5

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  • DOI: https://doi.org/10.1007/s11094-009-0175-5

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