A series of β-N-acylhydrazides of 4-aryl-2-hydroxy-4-oxo-2-butenoic (aroylpyruvic) acids have been synthesized in 80–90% yield via decyclization reactions of 5-aryl-2,3-dihydrofuran-2,3-diones with hydrazides of aromatic acids in anhydrous dioxane. Physicochemical characteristics of the products were determined. Their antimicrobial properties were examined.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
A. V. Milyutin, L. R. Amirova, R. R. Makhmudov, et al., in: Third Russian National Congress “Man and Medicine” [in Russian], Moscow (1996), p. 36.
O. V. Zvereva, A. V. Milyutin, T. F. Odegova, et al., Khim.-farm. Zh., 38(2), 32–33 (2004).
O. V. Zvereva, A. V. Milyutin, O. V. Bobrovskaya, et al., Khim.-farm. Zh., 39(3), 21–22 (2005).
A. V. Milyutin, N. V. Safonova, V. O. Koz'minykh, et al., Biologically Active Compounds, Synthesis and Use [in Russian], Penza (1992), pp. 56–57.
V. O. Koz'minykh, N. M. Igidov, V. I. Il'enko, et al., Khim.-farm. Zh., 26(7–8), 28–31 (1992).
L. N. Kurkovskaya, N. N. Shapet'ko, Yu. S. Andreichivov, et al., Zh. Strukt. Khim., 13(6), 1026–1032 (1972).
R. G. Glushkov, I. B. Levshin, N. B. Marchenko, et al., Khim.-farm. Zh., 18(9), 1048–1064 (1984).
R. A. Mokrushina, V. N. Charushin, and O. N. Chupakhin, Khim.-farm. Zh., 29(9), 5–19 (1995).
Author information
Authors and Affiliations
Additional information
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 42, No. 9, pp. 32–33, September, 2008.
Rights and permissions
About this article
Cite this article
Zvereva, O.V., Milyutin, A.V., Odegova, T.F. et al. Synthesis and antimicrobial activity of β-N-acylhydrazides of 4-aryl-2-hydroxy-4-oxo-2-butenoic (aroylpyruvic) acids. Pharm Chem J 42, 527–528 (2008). https://doi.org/10.1007/s11094-009-0174-6
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11094-009-0174-6