Reaction of the methyl esters of aroylpyruvic acids with mixtures of 4-(2-aminoethyl)benzenesulfonamide and an aromatic aldehyde was used to synthesize 1-[2-(4-aminosulfonylphenyl)ethyl]-5-aryl-4-aroyl-3-hydroxy- 3-pyrrolin-2-ones. The structures of these compounds were verified by IR and 1H NMR spectroscopy and mass spectrometry. Their antibacterial activity was studied.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 49, No. 9, pp. 32 – 34, September, 2015.
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Gein, V.L., Bobrovskaya, O.V., Valiev, R.T. et al. Synthesis and Antibacterial Activity of 1-[2-(4-Aminosulfonylphenyl)Ethyl]-5-Aryl-4-Aroyl-3-Hydroxy-3-Pyrrolin-2-Ones. Pharm Chem J 49, 602–604 (2015). https://doi.org/10.1007/s11094-015-1337-2
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DOI: https://doi.org/10.1007/s11094-015-1337-2