Skip to main content
SpringerLink
Log in

Synthesis and antimicrobial activity of sulfazine-containing copper(II) coordination compounds with substituted salicylaldehydebenzoylhydrazones

  • Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
  • Published:
Pharmaceutical Chemistry Journal Aims and scope

A series of new mixed-ligand coordination complexes of copper with sulfazine and benzoylhydrazones of salicylaldehyde and 5-chloro-, 5-bromo-, 5-nitro-, 3,5-dichloro-, and 3,5-dibromosalicylaldehydes have been synthesized. The compounds display high antimicrobial activity. The compositions and probable structures of the obtained complexes have been proposed on the basis of elemental analysis, magnetic measurements, IR spectroscopy, and thermogravimetric measurements. The influence of the anion and the substituent in the salicylaldehydebenzoylhydrazone fragment on the structure and antimicrobial activity of coordination compounds toward nine Gram-positive and Gram-negative microorganisms has been studied. Sulfazine-containing copper(II) chloride and bromide complexes obtained on the basis of 3,5-dibromosalicylaldehydebenzoylhydrazone showed the maximum antimicrobial activity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. N. M. Samus, V. I. Prisakar, V. I. Tsapkov, et al., Khim.-farm. Zh., 38(7), 27–29 (2004).

    Google Scholar 

  2. N. M. Samus, V. I. Tsapkov, T. A. Burdenko, et al., Khim.-farm. Zh., 29(12), 41–43 (1995).

    CAS  Google Scholar 

  3. V. V. Lukov, E. V. Bogatyreva, V. A. Kogan, et al., Zh. Neorg. Khim., 36(9), 2310–2316 (1991).

    CAS  Google Scholar 

  4. S. I. Levchenko, V. A. Kogan, and V. V. Lukov, Zh. Neorg. Khim., 38(11), 1992–1998 (1993).

    Google Scholar 

  5. M. Mohan, A. Kumar, M. Kumar, et al., Inorg. Chim. Acta, 136(19), 65–74 (1987).

    Article  CAS  Google Scholar 

  6. G. N. Pershin, Methods of Experimental Chemotherapy [in Russian], Meditsina, Moscow (1971), pp. 357–359.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. State University of Moldova, Chisinau, Moldova, Romania

    V. I. Tsapkov, D. V. Lazakovich & A. P. Gulya

  2. Testemitsanu State University of Medicine and Pharmacy, Chisinau, Moldova, Romania

    V. I. Prisacar & S. A. Buracheva

Authors
  1. V. I. Tsapkov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. I. Prisacar
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. A. Buracheva
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. D. V. Lazakovich
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. P. Gulya
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 42, No. 9, pp. 28–31, September, 2008.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tsapkov, V.I., Prisacar, V.I., Buracheva, S.A. et al. Synthesis and antimicrobial activity of sulfazine-containing copper(II) coordination compounds with substituted salicylaldehydebenzoylhydrazones. Pharm Chem J 42, 523–526 (2008). https://doi.org/10.1007/s11094-009-0173-7

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-009-0173-7

Keywords

Search

Navigation