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Preparation of lidocaine, bipuvacaine, mepivacaine, trimecaine, and pyromecaine by reductive acylation on palladium catalysts

  • Drug Synthesis Methods and Manufacturing Technology
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Abstract

A method for the catalytic synthesis of local anesthetics — lidocaine, bipuvacaine, mepivacaine, trimecaine, and pyromecaine — by reductive acylation is described. The process takes place in mild conditions (20–50°C, hydrogen at atmospheric pressure, organic solvent) with target product yields of 54–93%.

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Authors and Affiliations

  1. Derbent Branch, Ivanovo State University, Ivanovo, Russia

    M. G. Abdullaev, Z. Sh. Abdullaeva & A. N. Idrisova

  2. Ivanovo State University, Ivanovo, Russia

    M. V. Klyuev & B. K. Kurbanov

Authors
  1. M. G. Abdullaev
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  2. M. V. Klyuev
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  3. Z. Sh. Abdullaeva
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  4. B. K. Kurbanov
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  5. A. N. Idrisova
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 42, No. 6, pp. 46–48, June, 2008.

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Abdullaev, M.G., Klyuev, M.V., Abdullaeva, Z.S. et al. Preparation of lidocaine, bipuvacaine, mepivacaine, trimecaine, and pyromecaine by reductive acylation on palladium catalysts. Pharm Chem J 42, 357–359 (2008). https://doi.org/10.1007/s11094-008-0126-6

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  • DOI: https://doi.org/10.1007/s11094-008-0126-6

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