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Synthesis and Various Biological Properties of 3-(4-Benzylpiperizino)-1-(4-Ethoxyphenyl)-1-Alkyl(Aryl)-2-Phenylpropan-1-OL Dihydrochlorides

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Pharmaceutical Chemistry Journal Aims and scope

Aminomethylation of 1-(4-ethoxyphenyl)-2-phenylethanone yielded 3-(4-benzylpiperazin-1-yl)-1-(4-ethoxyphenyl)-2-phenylpropan-1-one. Reduction of this compound with lithium aluminum hydride produced 3-(4-benzylpiperazin-1-yl)-1-(4-ethoxyphenyl)-2-phenylpropan-1-one, and interaction of this with Grignard reagents produced 3-(4-benzylpiperazinyl)-1-(4-ethoxyphenyl)-1-alkyl(aryl)-2-phenylpropan-1-ones. Some of the dihydrochlorides of the resulting compounds were found to have anti-inflammatory, analgesic, and peripheral n-cholinolytic activity.

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Authors and Affiliations

  1. A. L. Mndzhoyan Scientific-Technical Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia, 26 Azatutyan Prospekt, 0014, Erevan, Armenia

    G. A. Gevorgyan, N. K. Gasparyan, O. A. Papoyan, A. E. Tumadzhyan, A. A. Tatevosyan & G. A. Panosyan

Authors
  1. G. A. Gevorgyan
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  2. N. K. Gasparyan
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  3. O. A. Papoyan
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  4. A. E. Tumadzhyan
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  5. A. A. Tatevosyan
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  6. G. A. Panosyan
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Correspondence to G. A. Gevorgyan.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 51, No. 1, pp. 31 – 34, January, 2017.

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Gevorgyan, G.A., Gasparyan, N.K., Papoyan, O.A. et al. Synthesis and Various Biological Properties of 3-(4-Benzylpiperizino)-1-(4-Ethoxyphenyl)-1-Alkyl(Aryl)-2-Phenylpropan-1-OL Dihydrochlorides. Pharm Chem J 51, 30–34 (2017). https://doi.org/10.1007/s11094-017-1552-0

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  • DOI: https://doi.org/10.1007/s11094-017-1552-0

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