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Functional derivatives of tetramic acid: New approaches to the synthesis of heterotricyclic compounds

  • Drug Synthesis Methods and Manufacturing Technology
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Abstract

A large group of 3-methylidene, 5-methylidene, and 3,5-dimethylidene derivatives, as well as pyrrolo-[3,4-b]indole and pyrrolo[3,4-b]quinoline derivatives, has been synthesized on the basis of pyrrolidine-2,4-dione (tetramic acid). Some of the synthesized 3,5-disubstituted pyrrolidine-2,4-diones exhibit anticonvulsant activity.

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Authors and Affiliations

  1. State Scientific Center for Antibiotics, Moscow, Russia

    I. K. Sorokina, L. M. Alekseeva, V. A. Parshin & V. G. Granik

Authors
  1. I. K. Sorokina
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  2. L. M. Alekseeva
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  3. V. A. Parshin
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  4. V. G. Granik
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Corresponding author

Correspondence to V. G. Granik.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 10, pp. 33–37, October, 2007.

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Sorokina, I.K., Alekseeva, L.M., Parshin, V.A. et al. Functional derivatives of tetramic acid: New approaches to the synthesis of heterotricyclic compounds. Pharm Chem J 41, 543–548 (2007). https://doi.org/10.1007/s11094-008-0009-x

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  • DOI: https://doi.org/10.1007/s11094-008-0009-x

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