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Comparative analysis of the effect of gestagens, antiestrogencytostatics, and androstenes on the viability of tumor and normal cells

  • Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
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Pharmaceutical Chemistry Journal Aims and scope

Abstract

The hormonal compound with the highest cytostatic activity against MCF-7 tumor cells (human breast cancer, BC) and the lowest activity against normal cells (rat skin fibroblasts) was sought among gestagens, androstenes, and antiestrogencytostatics. It was found that antiestrogencytostatics and androstenes had the highest cytostatic activity against tumor cells whereas gestagens and antiestrogencytostatics were least active against fibroblasts. Studies of the activity of the hormonal compounds in combination with doxorubicin on the viability of MCF-7 and rat skin fibroblasts found that all investigated compounds with the exception of dehydroepiandrosterone (DHEA) intensify the cytostatic activity of doxorubicin against tumor cells, the greatest effect seen for antiestrogencytostatics. A chemoprotective effect of androstenes on normal cells was noted.

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Authors and Affiliations

  1. Russian State Medical University, Moscow

    T. A. Fedotcheva, N. L. Shimanovskii, A. I. Senderovich, N. S. Chermnykh, A. V. Semeikin, V. V. Banin & P. V. Sergeev

  2. TsKhLS-VNIKhFI, Moscow

    G. S. Grinenko

  3. Endocrinology Scientific Center, RAMS, Moscow

    V. M. Rzheznikov & L. E. Golubovskaya

Authors
  1. T. A. Fedotcheva
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  2. N. L. Shimanovskii
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  3. A. I. Senderovich
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  4. N. S. Chermnykh
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  5. A. V. Semeikin
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  6. V. M. Rzheznikov
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  7. L. E. Golubovskaya
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  8. G. S. Grinenko
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  9. V. V. Banin
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  10. P. V. Sergeev
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Additional information

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 7, pp. 3–7, July, 2007.

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Fedotcheva, T.A., Shimanovskii, N.L., Senderovich, A.I. et al. Comparative analysis of the effect of gestagens, antiestrogencytostatics, and androstenes on the viability of tumor and normal cells. Pharm Chem J 41, 345–349 (2007). https://doi.org/10.1007/s11094-007-0078-2

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  • DOI: https://doi.org/10.1007/s11094-007-0078-2

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