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Selecting optimum thermal acid hydrolysis conditions for obtaining lactobacillus hydrolysates

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Pharmaceutical Chemistry Journal Aims and scope

Abstract

The conditions of thermal acid hydrolysis of lactobacillus mass were studied within the framework of the development of a new preparation possessing immunomodulating properties. The parameters for optimization were the process temperature and duration and pH of the medium. The optimization criteria were the contents of total and amine nitrogen, proteins, peptides, and amino sugars. The coefficients of hydrolysis and proteolysis were determined. Based on the analysis of data, hydrolysates containing 2% peptides and 0.02–0.03% amino sugars were selected for subsequent investigations.

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Authors and Affiliations

  1. Pyatigorsk State Pharmaceutical Academy, Pyatigorsk, Russia

    M. V. Gavrilin, G. V. Sen'chukova & S. P. Senchenko

  2. State Research Institute of Complex Processing of Dairy Raw Materials, Stavropol, Russia

    V. A. Samoilov & N. M. Gostishcheva

Authors
  1. M. V. Gavrilin
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  2. G. V. Sen'chukova
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  3. S. P. Senchenko
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  4. V. A. Samoilov
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  5. N. M. Gostishcheva
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 2, pp. 54–56, February, 2007.

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Gavrilin, M.V., Sen'chukova, G.V., Senchenko, S.P. et al. Selecting optimum thermal acid hydrolysis conditions for obtaining lactobacillus hydrolysates. Pharm Chem J 41, 115–118 (2007). https://doi.org/10.1007/s11094-007-0025-2

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  • DOI: https://doi.org/10.1007/s11094-007-0025-2

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