Abstract
A series of 2-(2-chloro-or 2-bromo-6-difluoromethoxyphenylamino)imidazoline hydrochlorides–clofelin analogs containing difluoromethoxy groups–have been synthesized. The introduction of difluoromethoxy groups decreases the toxicity, increases the duration of hypotensive action, and induces a less pronounced decrease in the heart rate in comparison to the action of clofelin.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 4, pp. 15–18, April, 2006.
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Yagupol’skii, L.M., Fialkov, Y.A. & Tarasova, E.V. Clofelin analogs containing difluoromethoxy groups. Pharm Chem J 40, 189–193 (2006). https://doi.org/10.1007/s11094-006-0089-4
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DOI: https://doi.org/10.1007/s11094-006-0089-4