Abstract
The possibility of obtaining paracetamol (4-acetamidophenol) and oxaphenamide (4-hydroxyphenylsalicylamide) by means of a single-stage reductive acylation of 4-nitrophenol on palladium catalysts has been studied. Using this single-stage reaction under mild conditions (organic solvents; temperature, 45°C; hydrogen pressure, 1 bar) the target compounds were obtained with a yield of 70–90% for paracetamol and 41–63% for oxaphenamide. Metal — polymer catalyst systems have proved to be more active and selective than the traditional heterogeneous Pd/C catalysts.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 39, No. 12, pp. 37–39, December, 2005.
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Abdullaev, M.G., Klyuev, M.V. 4-Aetaminophenol and 4-hydroxyphenylsalicylamide synthesized by reductive acylation of 4-nitrophenol on palladium catalysts. Pharm Chem J 39, 655–657 (2005). https://doi.org/10.1007/s11094-006-0040-8
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DOI: https://doi.org/10.1007/s11094-006-0040-8