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Monte Carlo simulation of photon migration in multi-component media

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Abstract

A Monte Carlo model of steady-state light transport in multi-layered tissues had been compiled in C language so that it could be applied on various computers easily. In the standard model of photon transport in a semi-infinite geometry, only a group of optical parameters are employed (the absorption coefficient, the scattering coefficient and the anisotropy factor). In order to properly simulate the multi-component media, we proposed a modified model in which we gave each component a weight based on its percentage composition in every layer of tissue or complex solution, while the MCML model [Monte Carlo model of light transport in multi-layered tissues by Wang et al. (Comput Meth Prog Biol 47:131–146, 1995)] cannot directly simulate the photon migration in multi-component media. The computational results using the modified model have been validated by existing analytical methods and the experiment. We have adopted the partial least-squares regression to measure the inner component’s percentage of the model solution of biological tissue, the percentage errors of both the calibration and prediction were \(>\)1 %. It has been proven that the modified model is able to effectively simulate the multi-component media. It also has a potential advantage to be a valid method for relevant applications in biomedical optics.

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Acknowledgments

This research was supported in part by the State Key Laboratory of Precision Measurement Technology and Instruments (Tianjin University) under the National Natural Science Foundation of China (No. 30973964) and Tianjin science and technology commission Program (No. 14JCZDJC33100).

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Authors and Affiliations

  1. State Key Laboratory of Precision Measurement Technology and Instruments, Tianjin University, Tianjin, 300072, China

    Wei Li, Ling Lin, Lei Bao & Longfei Zhao

  2. Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin University, Tianjin, 300072, China

    Gang Li

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  1. Wei Li
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  2. Ling Lin
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  3. Lei Bao
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  4. Longfei Zhao
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  5. Gang Li
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Correspondence to Ling Lin.

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Li, W., Lin, L., Bao, L. et al. Monte Carlo simulation of photon migration in multi-component media. Opt Quant Electron 47, 1919–1931 (2015). https://doi.org/10.1007/s11082-014-0058-1

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